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          microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression.

          Zhang Z1,2,3, Pi J1,2,3, Zou D4, Wang X1,2,3, Xu J1,2,3,5, Yu S1,2,3, Zhang T6, Li F7, Zhang X1,2 , 3, Zhao H1,2,3, Wang F1,2,3, Wang D8, Ma Y9,10,11, Yu J12,13,14
          Nat Commun. 2019 Sep 27; 10 (1): 4397
          PMID: 31562301
          Abstract
          Strand-selection is the final step of microRNA biogenesis in which functional mature miRNAs are generated from one or both arms of precursor. The preference of strand-selection is diverse during development and tissue formation, however, its pathological effect is still unknown. Here we find that two miRNA arms from the same precursor, miR-574-5p and miR-574-3p, are inversely expressed and play exactly opposite roles in gastric cancer progression. Higher-5p with lower-3p expression pattern is significantly correlated with higher TNM stages and poor prognosis of gastric cancer patients. The increase of miR-574-5p / -3p ratio, named miR-574 arm-imbalance is partially due to the dynamic expression of their highly complementary targets in gastric carcinogenesis, moreover, the arm- imbalance of miR-574 is in turn involved and further promotes gastric cancer progression. Our results indicate that miR-574 arm-imbalance contribute to gastric cancer progression and re-modification of the miR-574-t argets homeostasis may represent a promising strategy for gastric cancer therapy.